Synthesis and evaluation of small molecules bearing a benzyloxy


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Synthesis and evaluation of small molecules bearing a ....

A new series of small molecules bearing a benzyloxy substituent have been designed, synthesized and evaluated for hMAO inhibitory activity in vitro. Most of the compounds were potent and selective MAO-B inhibitors, and were weak inhibitors of MAO-A. In particular, compounds 9e (IC50 = 0.35 μM) and 10e (IC50

Looking for new antiplasmodial quinazolines: DMAP ....

A DMAP catalyzed synthesis of new 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines was studied, in a view to react 4-chloroquinazolines with poorly nucleophilic alcohols such as benzylic alcohols, via a simple and cheap S N Ar reaction approach. A fast (1 h) general operating procedure, affording good reaction yields, was achieved under microwave irradiation.

Synthesis, Biological Evaluation, and Molecular Modeling ....

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 2017, 125, 853-864. DOI: 10.1016/j.ejmech.2016.09.041. Diego Muñoz-Torrero.

Synthesis and Functional Evaluation of Novel Aldose ....

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold Maria Digiacomo §, Stefania Sartini §, Giulia Nesi, Simona Sestito, Vito Coviello, Concettina La Motta *, Simona Rapposelli *

Synthesis and Functional Evaluation of Novel Aldose ....

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold. ... and their benzyloxy analogs, developed as aldose reductase inhibitors. ... we developed a new class of small molecules bearing a benzopyran scaffold that displayed inhibitory activity against ARL2, ...

Synthesis and Functional Evaluation of Novel Aldose ....

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold. SPECIAL FEE WAIVER AND DISCOUNTS; ... we developed a new class of small molecules bearing a benzopyran scaffold that displayed inhibitory activity against ARL2, ... Synthesis, functional evaluation, and molecular modeling studies. J. Med.

Jing Yang's research works | Shanghai University of ....

Jing Yang's 5 research works with 19 citations and 71 reads, including: Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells

Synthesis and Functional Evaluation of Novel Aldose ....

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold. ... we developed a new class of small molecules bearing a benzopyran scaffold that displayed inhibitory activity against ... we replaced the benzopyran scaffold with the more flexible benzyloxy nucleus, thus synthesizing compounds 11 ...

Molecules | Free Full-Text | Synthesis of No-Carrier-Added ....

4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [18F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide ...

Molecules | Free Full-Text | New Synthesis Method for ....

The new rapid synthesis extended the method of ring-closing reaction of sulfonic acid lactone derivatives. The angiogenesis activities of S-CA were evaluated by the chick chorioallantoic membrane (CAM) model. It could selectively suppress small angiogenesis in CAM, without influencing either middle and large angiogenesis.

Selective inhibitors of monoamine oxidase (MAO-A and MAO-B) as probes of its catalytic site and mechanis...

3 Jin-Shuai Lan, Tong Zhang, Yun Liu, Yong Zhang, Jian-wei Hou, Sai-Sai Xie, Jing Yang, Yue Ding, Zhen-zhen Cai, Synthesis and evaluation of small molecules bearing a benzyloxy substituent as novel and potent monoamine oxidase inhibitors, MedChemComm, 2017, 8, 2, 471CrossRef

Synthesis and Functional Evaluation of Novel Aldose ....

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold. ... we developed a new class of small molecules bearing a benzopyran scaffold that displayed inhibitory activity against ... we replaced the benzopyran scaffold with the more flexible benzyloxy nucleus, thus synthesizing compounds 11 ...

Chemistry Tree - Yong Zha...

Lan JS, Zhang T, Liu Y, et al. (2017) Synthesis and evaluation of small molecules bearing a benzyloxy substituent as novel and potent monoamine oxidase inhibitors. Medchemcomm. 8: 471-478: Zhang Y, Wang Z, Ng MK, et al. (2007) Conformational reorganization and solvation dynamics of dendritic oligothiophenes. The Journal of Physical Chemistry.

Synthesis and evaluation of resins bearing substrate-like ....

Synthesis and evaluation of resins bearing substrate-like inhibitor functions for capturing copper amine oxidases ... either as small molecules or polymeric soluble and insoluble structures, that ...

Synthesis and Biological Evaluation of Some Novel ....

Title:Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors VOLUME: 16 ISSUE: 2 Author(s):Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng* Affiliation:Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, Henan Provincial Eye Hospital, Henan ...

Synthesis and biological evaluation of dihydrotriazine ....

Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents ... an important enzyme in the de novo pathway of purine and thymidine synthesis, and small molecules targeting this enzyme have ... Previously, we reported that rhodamine derivatives bearing benzyloxy benzaldehyde or benzyloxy naphthaldehyde ...

刘新泳 教授-山东大学药学...

synthesis and biological evaluation of heteroaryl substituted imidazole derivatives as potent Non-Nucleoside HBV ... synthesis and biological evaluation of 3-benzyloxy . ...

Bioorganic & Medicinal Chemistry Letters, 化学 • 材料, 药化 ....

therefore several small molecules acting as TRAIL-R agonists are emerging in the scientific literature. ... Design, synthesis and evaluation of novel, potent DNA (IF ...