Role of lubricin and boundary lubrication in the


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Role of lubricin and boundary lubrication in the ....

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Article in Proceedings of the National Academy of Sciences 110(15) · March 2013 with 30 Reads

Regulation of lubricin for functional cartilage tissue ....

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

The biology of Lubricin: Near frictionless joint motion ....

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

The role of lubricin in the mechanical behavior of ....

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., Laderer M.C., Breuer K.S. Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

The role of lubricin in normal and pathological joint tissue: a contemporary revi...

The aim of this article was to critically review the literature about lubricin and its involvement in normal and pathological joint tissue. In particular, our research focussed on new therapeutic approaches for the treatment of osteoarthritis related to lubricin. We reviewed the literature regarding lubricin expression.

Role of lubricin and boundary lubrication in the ....

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

Transcription, Translation, and Function of Lubricin, a ....

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Friction force microscopy of lubricin and hyaluronic acid ....

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

PNAS揭示关节炎防治新方法 - 生物...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Osteoarthritis is a complex disease involving the mechanical breakdown of articular ...

The role of lubricin in the ... - PubMed Central (PM...

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

Boundary mode lubrication of articular cartilage by ....

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

Boundary-Lubricating Ability and Lubricin in Synovial ....

In conclusion, this study showed that distinct changes in lubricin and boundary-lubricating ability in the SF occurred with different stages of TMDs. Further studies should elucidate the role of lubricin, boundary lubrication, and complex, intrinsic mechanisms implicated in TMDs.

Cartilage boundary lubrication synergism is mediated by ....

Background. Proteoglycan 4 (PRG4) and hyaluronan (HA) are key synovial fluid constituents that contribute synergistically to cartilage boundary lubrication; however, the effects of their concentrations as well as their structure, both of which can be altered in osteoarthritis, on this functional synergism are unknown.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Regulation of lubricin for functional cartilage tissue ....

lubricin is verified to carry its responsibility for antag-onizing abnormal cellular adhesion and overgrowth. The fundamental role of lubricin is lubrication of boundary surface of cartilage [18]. Hence, transmuta-tion of lubricin metabolism would conspicuously influ-ence joint performance. In fact, patients who suffer

Lubricin - Brown Universi...

provides lubrication but does not prevent wear, enabling a pencil to leave a residue (writing). Lubricin lubricates via the boundary mode which is a regime in the leftward area of the Striebek curve (Márton & Lantos, 2006). This means that boundary lubrication functions independently of synovial fluid viscosity.

Molecular synergy in biolubrication: The role of cartilage ....

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... M.L. Warman, G.D. JayRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc. Natl. Acad. Sci., 110 (15) (2013), pp. 5852-5857. Google Scholar.

NAVER Academic > Role of lubricin and boundary lubrication ....

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L ...

Supramolecular synergy in the boundary lubrication of ....

Boundary lubrication measured in the SFB arises from dissipation at the slip plane between the intimately contacting boundary layers ... The role of lubricin in the mechanical behavior of ...